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Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells

The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events. The basic-helix-loop-helix (bHLH) protein Atoh7 is a key neurogenic transcription factor required for RGC development. Here, we inves...

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Detalles Bibliográficos
Autores principales: Zhang, Xiang-Mei, Hashimoto, Takao, Tang, Ronald, Yang, Xian-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931526/
https://www.ncbi.nlm.nih.gov/pubmed/29717171
http://dx.doi.org/10.1038/s41598-018-25188-z