High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

Under diabetic conditions, sodium–glucose cotransporter 2 (SGLT2) for glucose uptake in proximal tubules (PTs) increases, whereas NAD(+)-dependent protein deacetylase silent mating type information regulation 2 homolog 1 (Sirtuin-1; SIRT1) for PT survival decreases. Therefore, we hypothesized that i...

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Detalles Bibliográficos
Autores principales: Umino, Hiroyuki, Hasegawa, Kazuhiro, Minakuchi, Hitoshi, Muraoka, Hirokazu, Kawaguchi, Takahisa, Kanda, Takeshi, Tokuyama, Hirobumi, Wakino, Shu, Itoh, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931531/
https://www.ncbi.nlm.nih.gov/pubmed/29717156
http://dx.doi.org/10.1038/s41598-018-25054-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931531/
https://www.ncbi.nlm.nih.gov/pubmed/29717156
http://dx.doi.org/10.1038/s41598-018-25054-y

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