UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

In Caenorhabditis elegans, two DNA glycosylases, UNG-1 and NTH-1, and two AP endonucleases, APN-1 and EXO-3, have been characterized from the base-excision repair (BER) pathway that repairs oxidatively modified DNA bases. UNG-1 removes uracil, while NTH-1 can remove 5-hydroxymethyluracil (5-hmU), an...

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Detalles Bibliográficos
Autores principales: Papaluca, Arturo, Wagner, J. Richard, Saragovi, H. Uri, Ramotar, Dindial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931555/
https://www.ncbi.nlm.nih.gov/pubmed/29717169
http://dx.doi.org/10.1038/s41598-018-25124-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931555/
https://www.ncbi.nlm.nih.gov/pubmed/29717169
http://dx.doi.org/10.1038/s41598-018-25124-1

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