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Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

Cytochrome P450 oxidoreductase (POR) is the primary electron donor in eukaryotic cytochrome P450 (CYP) containing systems. A wealth of ensemble biophysical studies of Cytochrome P450 oxidoreductase (POR) has reported a binary model of the conformational equilibrium directing its catalytic efficiency...

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Detalles Bibliográficos
Autores principales: Bavishi, Krutika, Li, Darui, Eiersholt, Stine, Hooley, Emma N., Petersen, Troels C., Møller, Birger Lindberg, Hatzakis, Nikos S., Laursen, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931563/
https://www.ncbi.nlm.nih.gov/pubmed/29717147
http://dx.doi.org/10.1038/s41598-018-24922-x