Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRI(ca)Col1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib)

Transforming growth factor-β (TGF-β) plays a crucial role in the pathogenesis of Systemic Sclerosis (SSc) and other fibrotic disorders. TGF-β-mediated c-Abl and Src kinase activation induces strong profibrotic cascade signaling. The purpose of this study was to test in vivo the antifibrotic activity...

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Detalles Bibliográficos
Autores principales: Wermuth, Peter J., Jimenez, Sergio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931634/
https://www.ncbi.nlm.nih.gov/pubmed/29718973
http://dx.doi.org/10.1371/journal.pone.0196559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931634/
https://www.ncbi.nlm.nih.gov/pubmed/29718973
http://dx.doi.org/10.1371/journal.pone.0196559

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