HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes. Here, HIV-1 adaptation studies were leveraged to ask whether viruses with an irreparable vif deletion could devel...

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Detalles Bibliográficos
Autores principales: Ikeda, Terumasa, Symeonides, Menelaos, Albin, John S., Li, Ming, Thali, Markus, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931688/
https://www.ncbi.nlm.nih.gov/pubmed/29677220
http://dx.doi.org/10.1371/journal.ppat.1007010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931688/
https://www.ncbi.nlm.nih.gov/pubmed/29677220
http://dx.doi.org/10.1371/journal.ppat.1007010

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