Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus of shark TcR. SHM in developing shark T cells likel...

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Detalles Bibliográficos
Autores principales: Ott, Jeannine A, Castro, Caitlin D, Deiss, Thaddeus C, Ohta, Yuko, Flajnik, Martin F, Criscitiello, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931798/
https://www.ncbi.nlm.nih.gov/pubmed/29664399
http://dx.doi.org/10.7554/eLife.28477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931798/
https://www.ncbi.nlm.nih.gov/pubmed/29664399
http://dx.doi.org/10.7554/eLife.28477

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