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Repurposing drugs in oncology (ReDO)—selective PDE5 inhibitors as anti-cancer agents

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina...

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Detalles Bibliográficos
Autores principales: Pantziarka, Pan, Sukhatme, Vidula, Crispino, Sergio, Bouche, Gauthier, Meheus, Lydie, Sukhatme, Vikas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931815/
https://www.ncbi.nlm.nih.gov/pubmed/29743944
http://dx.doi.org/10.3332/ecancer.2018.824