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Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas. Understanding mechanisms of piperaquine (PPQ) resistance is crucial for tracking its emergence and spread, and to develop effective strategies fo...

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Detalles Bibliográficos
Autores principales: Bopp, Selina, Magistrado, Pamela, Wong, Wesley, Schaffner, Stephen F., Mukherjee, Angana, Lim, Pharath, Dhorda, Mehul, Amaratunga, Chanaki, Woodrow, Charles J., Ashley, Elizabeth A., White, Nicholas J., Dondorp, Arjen M., Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Wirth, Dyann F., Volkman, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931971/
https://www.ncbi.nlm.nih.gov/pubmed/29720620
http://dx.doi.org/10.1038/s41467-018-04104-z