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Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A

Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectopic bone formation and osteolysis related to osteosarcoma. H...

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Detalles Bibliográficos
Autores principales: de Ridder, Daniëlle, Marino, Silvia, Bishop, Ryan T., Renema, Nathalie, Chenu, Chantal, Heymann, Dominique, Idris, Aymen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932056/
https://www.ncbi.nlm.nih.gov/pubmed/29720701
http://dx.doi.org/10.1038/s41598-018-25290-2