AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Detalles Bibliográficos
Autores principales: Di Rita, Anthea, D’Acunzo, Pasquale, Simula, Luca, Campello, Silvia, Strappazzon, Flavie, Cecconi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932353/
https://www.ncbi.nlm.nih.gov/pubmed/29755319
http://dx.doi.org/10.3389/fncel.2018.00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932353/
https://www.ncbi.nlm.nih.gov/pubmed/29755319
http://dx.doi.org/10.3389/fncel.2018.00092

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