Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase

Novel therapeutic means against Staphylococcus aureus infections are urgently needed due to the emergence of drug-resistant S. aureus. We report the development of a CRISPR RNA-guided cytidine deaminase (pnCasSA–BEC), enabling highly efficient gene inactivation and point mutations in S. aureus. We e...

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Detalles Bibliográficos
Autores principales: Gu, Tongnian, Zhao, Siqi, Pi, Yishuang, Chen, Weizhong, Chen, Chuanyuan, Liu, Qian, Li, Min, Han, Dali, Ji, Quanjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932532/
https://www.ncbi.nlm.nih.gov/pubmed/29780457
http://dx.doi.org/10.1039/c8sc00637g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932532/
https://www.ncbi.nlm.nih.gov/pubmed/29780457
http://dx.doi.org/10.1039/c8sc00637g

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