In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, its mutational signature has not been delineated. We hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Boot, Arnoud, Huang, Mi Ni, Ng, Alvin W.T., Ho, Szu-Chi, Lim, Jing Quan, Kawakami, Yoshiiku, Chayama, Kazuaki, Teh, Bin Tean, Nakagawa, Hidewaki, Rozen, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932606/
https://www.ncbi.nlm.nih.gov/pubmed/29632087
http://dx.doi.org/10.1101/gr.230219.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932606/
https://www.ncbi.nlm.nih.gov/pubmed/29632087
http://dx.doi.org/10.1101/gr.230219.117

Ejemplares similares