In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors

Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3′ splice sites and recruits the spliceosome. We establish “in vitro iCLIP” experiments, in which recombin...

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Detalles Bibliográficos
Autores principales: Sutandy, F.X. Reymond, Ebersberger, Stefanie, Huang, Lu, Busch, Anke, Bach, Maximilian, Kang, Hyun-Seo, Fallmann, Jörg, Maticzka, Daniel, Backofen, Rolf, Stadler, Peter F., Zarnack, Kathi, Sattler, Michael, Legewie, Stefan, König, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932610/
https://www.ncbi.nlm.nih.gov/pubmed/29643205
http://dx.doi.org/10.1101/gr.229757.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932610/
https://www.ncbi.nlm.nih.gov/pubmed/29643205
http://dx.doi.org/10.1101/gr.229757.117

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