In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors

Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3′ splice sites and recruits the spliceosome. We establish “in vitro iCLIP” experiments, in which recombin...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutandy, F.X. Reymond, Ebersberger, Stefanie, Huang, Lu, Busch, Anke, Bach, Maximilian, Kang, Hyun-Seo, Fallmann, Jörg, Maticzka, Daniel, Backofen, Rolf, Stadler, Peter F., Zarnack, Kathi, Sattler, Michael, Legewie, Stefan, König, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932610/
https://www.ncbi.nlm.nih.gov/pubmed/29643205
http://dx.doi.org/10.1101/gr.229757.117

Ejemplares similares

Ejemplares similares