Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

BACKGROUND: Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction mo...

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Detalles Bibliográficos
Autores principales: Cutolo, Maurizio, Ruaro, Barbara, Montagna, Paola, Brizzolara, Renata, Stratta, Emanuela, Trombetta, Amelia Chiara, Scabini, Stefano, Tavilla, Pier Paolo, Parodi, Aurora, Corallo, Claudio, Giordano, Nicola, Paolino, Sabrina, Pizzorni, Carmen, Sulli, Alberto, Smith, Vanessa, Soldano, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932791/
https://www.ncbi.nlm.nih.gov/pubmed/29720235
http://dx.doi.org/10.1186/s13075-018-1577-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932791/
https://www.ncbi.nlm.nih.gov/pubmed/29720235
http://dx.doi.org/10.1186/s13075-018-1577-0

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