Cargando…

Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

BACKGROUND: Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosis (SSc) by the activation of fibrogenic intracellular signaling transduction mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cutolo, Maurizio, Ruaro, Barbara, Montagna, Paola, Brizzolara, Renata, Stratta, Emanuela, Trombetta, Amelia Chiara, Scabini, Stefano, Tavilla, Pier Paolo, Parodi, Aurora, Corallo, Claudio, Giordano, Nicola, Paolino, Sabrina, Pizzorni, Carmen, Sulli, Alberto, Smith, Vanessa, Soldano, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932791/ https://www.ncbi.nlm.nih.gov/pubmed/29720235 http://dx.doi.org/10.1186/s13075-018-1577-0

Ejemplares similares

Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay
por: Cutolo, Maurizio, et al.
Publicado: (2018)

Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
por: Soldano, Stefano, et al.
Publicado: (2016)

Correction: Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
por: Soldano, Stefano, et al.
Publicado: (2017)

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity
por: Cutolo, Maurizio, et al.
Publicado: (2021)

Correction: Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity
por: Cutolo, Maurizio, et al.
Publicado: (2023)

A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement
por: Trombetta, Amelia Chiara, et al.
Publicado: (2018)

Endothelin and sex hormones modulate the fibronectin synthesis by cultured human skin scleroderma fibroblasts
por: Soldano, S, et al.
Publicado: (2008)

CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients
por: Cutolo, Maurizio, et al.
Publicado: (2021)

A Systematic Review of Aminaphtone from Pathophysiology to Clinical Applications: Focus on New Rheumatological Acquisitions
por: Gotelli, Emanuele, et al.
Publicado: (2023)

Subclinical dermal involvement is detectable by high frequency ultrasound even in patients with limited cutaneous systemic sclerosis
por: Sulli, A., et al.
Publicado: (2017)

Vitamin D and COVID-19: Narrative Review after 3 Years of Pandemic
por: Gotelli, Emanuele, et al.
Publicado: (2022)

Vitamin D deficiency and clinical correlations in systemic sclerosis patients: A retrospective analysis for possible future developments
por: Trombetta, Amelia Chiara, et al.
Publicado: (2017)

Innovations in the Assessment of Primary and Secondary Raynaud’s Phenomenon
por: Ruaro, Barbara, et al.
Publicado: (2019)

Understanding the Immune-Endocrine Effects of Vitamin D in SARS-CoV-2 Infection: A Role in Protecting against Neurodamage
por: Gotelli, Emanuele, et al.
Publicado: (2023)

Antibodies against specific extractable nuclear antigens (ENAs) as diagnostic and prognostic tools and inducers of a profibrotic phenotype in cultured human skin fibroblasts: are they functional?
por: Corallo, Claudio, et al.
Publicado: (2019)

Aminaphtone Efficacy in Primary and Secondary Raynaud’s Phenomenon: A Feasibility Study
por: Ruaro, Barbara, et al.
Publicado: (2019)

CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
por: Cutolo, Maurizio, et al.
Publicado: (2009)

Methods for the morphological and functional evaluation of microvascular damage in systemic sclerosis
por: Ruaro, Barbara, et al.
Publicado: (2015)

Influence of Seasonal Vitamin D Changes on Clinical Manifestations of Rheumatoid Arthritis and Systemic Sclerosis
por: Cutolo, Maurizio, et al.
Publicado: (2021)

Fli1 Downregulation in Scleroderma Myeloid Cells Has Profibrotic and Proinflammatory Effects
por: Bujor, Andreea M., et al.
Publicado: (2020)

Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients
por: Ruaro, Barbara, et al.
Publicado: (2020)

Capillaroscopy as an Outcome Measure for Clinical Trials on the Peripheral Vasculopathy in SSc—Is It Useful?
por: Cutolo, Maurizio, et al.
Publicado: (2010)

Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions
por: Midgley, Adam C., et al.
Publicado: (2020)

Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis
por: Gabasa, Marta, et al.
Publicado: (2017)

A Profibrotic Phenotype in Naïve and in Fibrotic Lung Myofibroblasts Is Governed by Modulations in Thy-1 Expression and Activation
por: Cohen, Pazit Y., et al.
Publicado: (2018)

The dichotomy of glucocorticosteroid treatment in immune-inflammatory rheumatic diseases: an evidence-based perspective and insights from clinical practice
por: Hysa, Elvis, et al.
Publicado: (2023)

Glucocorticoid management in rheumatoid arthritis: morning or night low dose?
por: Paolino, Sabrina, et al.
Publicado: (2017)

Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts
por: Spathakis, Michail, et al.
Publicado: (2023)

Lipoxin A(4) Attenuates Constitutive and TGF-β1–Dependent Profibrotic Activity in Human Lung Myofibroblasts
por: Roach, Katy M., et al.
Publicado: (2015)

Vitamin D and Lung Outcomes in Elderly COVID-19 Patients
por: Sulli, Alberto, et al.
Publicado: (2021)

Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts
por: Raschi, Elena, et al.
Publicado: (2018)

Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles
por: Luo, Shun-bin, et al.
Publicado: (2021)

Selexipag for pulmonary arterial hypertension
Publicado: (2021)

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy
por: Romano, Eloisa, et al.
Publicado: (2021)

Understanding the value of non-specific abnormal capillary dilations in presence of Raynaud’s phenomenon: a detailed capillaroscopic analysis
por: Pacini, Greta, et al.
Publicado: (2022)

Specific Autoantibodies and Microvascular Damage Progression Assessed by Nailfold Videocapillaroscopy in Systemic Sclerosis: Are There Peculiar Associations? An Update
por: Hysa, Elvis, et al.
Publicado: (2023)

Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma
por: Leask, Andrew
Publicado: (2012)

Detailed videocapillaroscopic microvascular changes detectable in adult COVID-19 survivors
por: Sulli, Alberto, et al.
Publicado: (2022)

Epstein–Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast–Myofibroblast Conversion in Scleroderma
por: Farina, Antonella, et al.
Publicado: (2014)

Pharmacological counseling in hepatotoxicity induced by macitentan and selexipag: a case report
por: Lattanzio, Mariangela, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qk2s73g8e21ace3e696366f04q