Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus

BACKGROUND: Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in th...

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Detalles Bibliográficos
Autores principales: Cole, Suzanne, Walsh, Alice, Yin, Xuefeng, Wechalekar, Mihir D., Smith, Malcolm D., Proudman, Susanna M., Veale, Douglas J., Fearon, Ursula, Pitzalis, Costantino, Humby, Frances, Bombardieri, Michele, Axel, Amy, Adams, Homer, Chiu, Christopher, Sharp, Michael, Alvarez, John, Anderson, Ian, Madakamutil, Loui, Nagpal, Sunil, Guo, Yanxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932888/
https://www.ncbi.nlm.nih.gov/pubmed/29720240
http://dx.doi.org/10.1186/s13075-018-1578-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932888/
https://www.ncbi.nlm.nih.gov/pubmed/29720240
http://dx.doi.org/10.1186/s13075-018-1578-z

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