Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells

The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from...

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Detalles Bibliográficos
Autores principales: Ramsuran, Veron, Naranbhai, Vivek, Horowitz, Amir, Qi, Ying, Martin, Maureen P., Yuki, Yuko, Gao, Xiaojiang, Walker-Sperling, Victoria, Del Prete, Gregory Q., Schneider, Douglas K., Lifson, Jeffrey D., Fellay, Jacques, Deeks, Steven G., Martin, Jeffrey N., Goedert, James J., Wolinsky, Steven M., Michael, Nelson L., Kirk, Gregory D., Buchbinder, Susan, Haas, David, Ndung’u, Thumbi, Goulder, Philip, Parham, Peter, Walker, Bruce D., Carlson, Jonathan M., Carrington, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933048/
https://www.ncbi.nlm.nih.gov/pubmed/29302013
http://dx.doi.org/10.1126/science.aam8825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933048/
https://www.ncbi.nlm.nih.gov/pubmed/29302013
http://dx.doi.org/10.1126/science.aam8825

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