Enantiocontrol by assembled attractive interactions in copper-catalyzed asymmetric direct alkynylation of α-ketoesters with terminal alkynes: OH···O/sp(3)-CH···O two-point hydrogen bonding combined with dispersive attractions

Copper-catalyzed asymmetric direct alkynylation of α-ketoesters with terminal alkynes with chiral prolinol–phosphine ligands, most preferably (αR,2S)-1-(2-dicyclohexylphosphinobenzyl)-α-neopentyl-2-pyrrolidinemethanol, afforded various enantioenriched chiral propargylic tertiary alcohols. Quantum-ch...

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Detalles Bibliográficos
Autores principales: Schwarzer, Martin C., Fujioka, Akane, Ishii, Takaoki, Ohmiya, Hirohisa, Mori, Seiji, Sawamura, Masaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933290/
https://www.ncbi.nlm.nih.gov/pubmed/29780478
http://dx.doi.org/10.1039/c8sc00527c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933290/
https://www.ncbi.nlm.nih.gov/pubmed/29780478
http://dx.doi.org/10.1039/c8sc00527c

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