Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Advances in the hematopoietic stem cell (HSCs) field have been aided by methods to genetically engineer primary progenitor cells as well as animal models. Complete gene ablation in HSCs required the generation of knockout mice from which HSCs could be isolated, and gene ablation in primary human HSC...

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Detalles Bibliográficos
Autores principales: Brunetti, Lorenzo, Gundry, Michael C., Kitano, Ayumi, Nakada, Daisuke, Goodell, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933422/
https://www.ncbi.nlm.nih.gov/pubmed/29708546
http://dx.doi.org/10.3791/57278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933422/
https://www.ncbi.nlm.nih.gov/pubmed/29708546
http://dx.doi.org/10.3791/57278

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