Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids

Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ). Polar interactions between receptor and ligand are important for binding and facilitating the non-polar interactions and...

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Detalles Bibliográficos
Autores principales: Haffez, Hesham, Chisholm, David R., Tatum, Natalie J., Valentine, Roy, Redfern, Christopher, Pohl, Ehmke, Whiting, Andrew, Przyborski, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933457/
https://www.ncbi.nlm.nih.gov/pubmed/29439915
http://dx.doi.org/10.1016/j.bmc.2018.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933457/
https://www.ncbi.nlm.nih.gov/pubmed/29439915
http://dx.doi.org/10.1016/j.bmc.2018.02.002

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