Pharmacological characterization of potent and selective Na(V)1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Identification of voltage-gated sodium channel Na(V)1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophysiology screening of fractionated tarantula veno...

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Detalles Bibliográficos
Autores principales: Moyer, Bryan D., Murray, Justin K., Ligutti, Joseph, Andrews, Kristin, Favreau, Philippe, Jordan, John B., Lee, Josie H., Liu, Dong, Long, Jason, Sham, Kelvin, Shi, Licheng, Stöcklin, Reto, Wu, Bin, Yin, Ruoyuan, Yu, Violeta, Zou, Anruo, Biswas, Kaustav, Miranda, Les P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933747/
https://www.ncbi.nlm.nih.gov/pubmed/29723257
http://dx.doi.org/10.1371/journal.pone.0196791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933747/
https://www.ncbi.nlm.nih.gov/pubmed/29723257
http://dx.doi.org/10.1371/journal.pone.0196791

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