Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show selectivity against dual-specificity tyrosine phosp...

Descripción completa

Detalles Bibliográficos
Autores principales: Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933782/
https://www.ncbi.nlm.nih.gov/pubmed/29723265
http://dx.doi.org/10.1371/journal.pone.0196761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933782/
https://www.ncbi.nlm.nih.gov/pubmed/29723265
http://dx.doi.org/10.1371/journal.pone.0196761

Ejemplares similares