Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Acquired drug resistance prevents cancer therapies from achieving stable and complete responses.(1) Emerging evidence implicates a key role for nonmutational drug resistance mechanisms underlying the survival of residual cancer “persister” cells.(2-4) The persister cell pool constitutes a reservoir...

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Detalles Bibliográficos
Autores principales: Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933935/
https://www.ncbi.nlm.nih.gov/pubmed/29088702
http://dx.doi.org/10.1038/nature24297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933935/
https://www.ncbi.nlm.nih.gov/pubmed/29088702
http://dx.doi.org/10.1038/nature24297

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