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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses.(1) Emerging evidence implicates a key role for nonmutational drug resistance mechanisms underlying the survival of residual cancer “persister” cells.(2-4) The persister cell pool constitutes a reservoir...
Autores principales: | Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933935/ https://www.ncbi.nlm.nih.gov/pubmed/29088702 http://dx.doi.org/10.1038/nature24297 |
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