Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for treatment of advanced metastatic tumors. Bisindolylmaleim...

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Detalles Bibliográficos
Autores principales: Li, Xia, Ma, Hongguang, Li, Lin, Chen, Yifan, Sun, Xiao, Dong, Zizheng, Liu, Jing-Yuan, Zhu, Weiming, Zhang, Jian-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934316/
https://www.ncbi.nlm.nih.gov/pubmed/29456240
http://dx.doi.org/10.1038/s41388-017-0076-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934316/
https://www.ncbi.nlm.nih.gov/pubmed/29456240
http://dx.doi.org/10.1038/s41388-017-0076-0

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