Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K

The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps by a three-comp...

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Detalles Bibliográficos
Autores principales: Rout, Manoj K., Lee, Brian L., Lin, Aiyang, Xiao, Wei, Spyracopoulos, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934386/
https://www.ncbi.nlm.nih.gov/pubmed/29725124
http://dx.doi.org/10.1038/s41598-018-25476-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934386/
https://www.ncbi.nlm.nih.gov/pubmed/29725124
http://dx.doi.org/10.1038/s41598-018-25476-8

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