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Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K
The ubiquitin proteasome system (UPS) signals for degradation of proteins through attachment of K48-linked polyubiquitin chains, or alterations in protein-protein recognition through attachment of K63-linked chains. Target proteins are ubiquitinated in three sequential chemical steps by a three-comp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934386/ https://www.ncbi.nlm.nih.gov/pubmed/29725124 http://dx.doi.org/10.1038/s41598-018-25476-8 |