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Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

Hepatitis C virus (HCV) envelope glycoprotein heterodimer, E1E2, plays an essential role in virus entry and assembly. Furthermore, due to their exposure at the surface of the virion, these proteins are the major targets of anti-HCV neutralizing antibodies. Their ectodomain are heavily glycosylated w...

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Detalles Bibliográficos
Autores principales: Lavie, Muriel, Hanoulle, Xavier, Dubuisson, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934428/
https://www.ncbi.nlm.nih.gov/pubmed/29755477
http://dx.doi.org/10.3389/fimmu.2018.00910