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Identification of Loop D Domain Amino Acids in the Human Aquaporin-1 Channel Involved in Activation of the Ionic Conductance and Inhibition by AqB011

Aquaporins are integral proteins that facilitate the transmembrane transport of water and small solutes. In addition to enabling water flux, mammalian Aquaporin-1 (AQP1) channels activated by cyclic GMP can carry non-selective monovalent cation currents, selectively blocked by arylsulfonamide compou...

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Detalles Bibliográficos
Autores principales: Kourghi, Mohamad, De Ieso, Michael L., Nourmohammadi, Saeed, Pei, Jinxin V., Yool, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934433/
https://www.ncbi.nlm.nih.gov/pubmed/29755973
http://dx.doi.org/10.3389/fchem.2018.00142