Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA

Cellular senescence can be induced by high levels of reactive oxygen species (ROS) produced by mitochondria. However, the mechanism by which elevated mitochondrial ROS levels are produced during replicative senescence is not yet fully understood. Here, we report that loss of the RNA-binding protein,...

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Detalles Bibliográficos
Autores principales: Lee, Ji Hoon, Jung, Misun, Hong, Juyeong, Kim, Mi Kyung, Chung, In Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934620/
https://www.ncbi.nlm.nih.gov/pubmed/29584879
http://dx.doi.org/10.1093/nar/gky223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934620/
https://www.ncbi.nlm.nih.gov/pubmed/29584879
http://dx.doi.org/10.1093/nar/gky223

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