A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping

Efficient γ-herpesvirus lytic phase replication requires a virally encoded UNG-type uracil-DNA glycosylase as a structural element of the viral replisome. Uniquely, γ-herpesvirus UNGs carry a seven or eight residue insertion of variable sequence in the otherwise highly conserved minor-groove DNA bin...

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Detalles Bibliográficos
Autores principales: Earl, Christopher, Bagnéris, Claire, Zeman, Kara, Cole, Ambrose, Barrett, Tracey, Savva, Renos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934625/
https://www.ncbi.nlm.nih.gov/pubmed/29596604
http://dx.doi.org/10.1093/nar/gky217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934625/
https://www.ncbi.nlm.nih.gov/pubmed/29596604
http://dx.doi.org/10.1093/nar/gky217

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