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Reconstructing spatial organizations of chromosomes through manifold learning

Decoding the spatial organizations of chromosomes has crucial implications for studying eukaryotic gene regulation. Recently, chromosomal conformation capture based technologies, such as Hi-C, have been widely used to uncover the interaction frequencies of genomic loci in a high-throughput and genom...

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Detalles Bibliográficos
Autores principales: Zhu, Guangxiang, Deng, Wenxuan, Hu, Hailin, Ma, Rui, Zhang, Sai, Yang, Jinglin, Peng, Jian, Kaplan, Tommy, Zeng, Jianyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934626/
https://www.ncbi.nlm.nih.gov/pubmed/29408992
http://dx.doi.org/10.1093/nar/gky065