Role for first zinc finger of WT1 in DNA sequence specificity: Denys–Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites

Wilms tumor protein (WT1) is a Cys2-His2 zinc-finger transcription factor vital for embryonic development of the genitourinary system. The protein contains a C-terminal DNA binding domain with four tandem zinc-fingers (ZF1–4). An alternative splicing of Wt1 can add three additional amino acids—lysin...

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Detalles Bibliográficos
Autores principales: Wang, Dongxue, Horton, John R, Zheng, Yu, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934627/
https://www.ncbi.nlm.nih.gov/pubmed/29294058
http://dx.doi.org/10.1093/nar/gkx1274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934627/
https://www.ncbi.nlm.nih.gov/pubmed/29294058
http://dx.doi.org/10.1093/nar/gkx1274

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