PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation

HIF1α (hypoxia inducible factor 1α) is the central regulator of the cellular response to low oxygen and its activity is deregulated in multiple human pathologies. Consequently, given the importance of HIF signaling in disease, there is considerable interest in developing strategies to modulate HIF1α...

Descripción completa

Detalles Bibliográficos
Autores principales: Ivanova, Iglika G, Park, Catherine V, Yemm, Adrian I, Kenneth, Niall S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934640/
https://www.ncbi.nlm.nih.gov/pubmed/29529249
http://dx.doi.org/10.1093/nar/gky127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934640/
https://www.ncbi.nlm.nih.gov/pubmed/29529249
http://dx.doi.org/10.1093/nar/gky127

Ejemplares similares