A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing

STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce type I interferon (IFN) production. Particularly, STING is activated by 2′3′-cGAMP, a cyclic dinucleotide containing mixed phosphodiester linkages and produced by cytopla...

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Detalles Bibliográficos
Autores principales: Wang, Pei-Hui, Fung, Sin-Yee, Gao, Wei-Wei, Deng, Jian-Jun, Cheng, Yun, Chaudhary, Vidyanath, Yuen, Kit-San, Ho, Ting-Hin, Chan, Ching-Ping, Zhang, Yan, Kok, Kin-Hang, Yang, Wanling, Chan, Chi-Ping, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934658/
https://www.ncbi.nlm.nih.gov/pubmed/29547894
http://dx.doi.org/10.1093/nar/gky186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934658/
https://www.ncbi.nlm.nih.gov/pubmed/29547894
http://dx.doi.org/10.1093/nar/gky186

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