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Pathogenic CTC1 mutations cause global genome instabilities under replication stress

Coats plus syndrome is a complex genetic disorder that can be caused by mutations in genes encoding the CTC1–STN1–TEN1 (CST) complex, a conserved single-stranded DNA binding protein complex. Studies have demonstrated that mutations identified in Coats plus patients are defective in telomere maintena...

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Detalles Bibliográficos
Autores principales: Wang, Yuan, Chai, Weihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934659/
https://www.ncbi.nlm.nih.gov/pubmed/29481669
http://dx.doi.org/10.1093/nar/gky114