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Pathogenic CTC1 mutations cause global genome instabilities under replication stress
Coats plus syndrome is a complex genetic disorder that can be caused by mutations in genes encoding the CTC1–STN1–TEN1 (CST) complex, a conserved single-stranded DNA binding protein complex. Studies have demonstrated that mutations identified in Coats plus patients are defective in telomere maintena...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934659/ https://www.ncbi.nlm.nih.gov/pubmed/29481669 http://dx.doi.org/10.1093/nar/gky114 |