GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

DNA repeat expansion underlies dozens of progressive neurodegenerative disorders. While the mechanisms driving repeat expansion are not fully understood, increasing evidence suggests a central role for DNA mismatch repair. The mismatch repair recognition complex MutSβ (MSH2-MSH3) that binds mismatch...

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Detalles Bibliográficos
Autores principales: Halabi, Anasheh, Fuselier, Kayla T B, Grabczyk, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934671/
https://www.ncbi.nlm.nih.gov/pubmed/29529236
http://dx.doi.org/10.1093/nar/gky143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934671/
https://www.ncbi.nlm.nih.gov/pubmed/29529236
http://dx.doi.org/10.1093/nar/gky143

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