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Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however, structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulc...

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Detalles Bibliográficos
Autores principales: Xu, Qun, Khan, Ashraf, Gao, Di, Adams, Kristie M., Tadjimukhamedov, Fatkhulla, Tan, Shane, Simpson, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934740/
https://www.ncbi.nlm.nih.gov/pubmed/29736295
http://dx.doi.org/10.1016/j.jpha.2017.12.007