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The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement

BACKGROUND: LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities. Although the actions of leptin and lepR in the control of reproductive function are thought to be exerted mainly via the hypothalamic-...

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Detalles Bibliográficos
Autores principales: Tu, Xiaoyu, Liu, Miao, Tang, Jianan, Zhang, Yu, Shi, Yan, Yu, Lin, Sun, Zhaogui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934784/
https://www.ncbi.nlm.nih.gov/pubmed/29728128
http://dx.doi.org/10.1186/s12958-018-0365-7