Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading. Clathrin-mediated endocytosis is needed for the formation of new SVs, yet it is unclear when endocytosed ves...

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Detalles Bibliográficos
Autores principales: Farsi, Zohreh, Gowrisankaran, Sindhuja, Krunic, Matija, Rammner, Burkhard, Woehler, Andrew, Lafer, Eileen M, Mim, Carsten, Jahn, Reinhard, Milosevic, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935483/
https://www.ncbi.nlm.nih.gov/pubmed/29652249
http://dx.doi.org/10.7554/eLife.32569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935483/
https://www.ncbi.nlm.nih.gov/pubmed/29652249
http://dx.doi.org/10.7554/eLife.32569

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