Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol. However, the determinants of TDP-43 localization and the cellular insults that promot...

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Detalles Bibliográficos
Autores principales: Pinarbasi, Emile S., Cağatay, Tolga, Fung, Ho Yee Joyce, Li, Ying C., Chook, Yuh Min, Thomas, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935693/
https://www.ncbi.nlm.nih.gov/pubmed/29728608
http://dx.doi.org/10.1038/s41598-018-25008-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935693/
https://www.ncbi.nlm.nih.gov/pubmed/29728608
http://dx.doi.org/10.1038/s41598-018-25008-4

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