The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells

Tyrosine kinase 2 (TYK2) belongs to the Janus kinase (JAK) family of tyrosine kinases, which transmit signals from activated cytokine receptors. GWAS have consistently implicated TYK2 in psoriasis susceptibility. We performed an in-depth association analysis of TYK2 using GWAS and resequencing data....

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Detalles Bibliográficos
Autores principales: Enerbäck, C., Sandin, C., Lambert, S., Zawistowski, M., Stuart, P. E., Verma, D., Tsoi, L. C., Nair, R. P., Johnston, A., Elder, J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935702/
https://www.ncbi.nlm.nih.gov/pubmed/29728633
http://dx.doi.org/10.1038/s41598-018-25282-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935702/
https://www.ncbi.nlm.nih.gov/pubmed/29728633
http://dx.doi.org/10.1038/s41598-018-25282-2

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