Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology

Although, a number of pathogenic mutations have been found for Alzheimer’s disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3′-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-i...

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Detalles Bibliográficos
Autores principales: Nagata, Kenichi, Takahashi, Mika, Matsuba, Yukio, Okuyama-Uchimura, Fumi, Sato, Kaori, Hashimoto, Shoko, Saito, Takashi, Saido, Takaomi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935712/
https://www.ncbi.nlm.nih.gov/pubmed/29728560
http://dx.doi.org/10.1038/s41467-018-04238-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935712/
https://www.ncbi.nlm.nih.gov/pubmed/29728560
http://dx.doi.org/10.1038/s41467-018-04238-0

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