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Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
Although, a number of pathogenic mutations have been found for Alzheimer’s disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3′-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-i...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935712/ https://www.ncbi.nlm.nih.gov/pubmed/29728560 http://dx.doi.org/10.1038/s41467-018-04238-0 |