Pathological conversion of regulatory T cells is associated with loss of allotolerance

CD4(+)CD25(+)Foxp3(+) Regulatory T cells (Tregs) play a critical role in immune tolerance. The plasticity and functional adaptability of Tregs in an inflammatory microenvironment has been demonstrated in autoimmunity. Here, using a double transgenic mouse model that permits Foxp3 lineage tracing, we...

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Detalles Bibliográficos
Autores principales: Hua, Jing, Inomata, Takenori, Chen, Yihe, Foulsham, William, Stevenson, William, Shiang, Tina, Bluestone, Jeffrey A., Dana, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935752/
https://www.ncbi.nlm.nih.gov/pubmed/29728574
http://dx.doi.org/10.1038/s41598-018-25384-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935752/
https://www.ncbi.nlm.nih.gov/pubmed/29728574
http://dx.doi.org/10.1038/s41598-018-25384-x

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