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Pathological conversion of regulatory T cells is associated with loss of allotolerance
CD4(+)CD25(+)Foxp3(+) Regulatory T cells (Tregs) play a critical role in immune tolerance. The plasticity and functional adaptability of Tregs in an inflammatory microenvironment has been demonstrated in autoimmunity. Here, using a double transgenic mouse model that permits Foxp3 lineage tracing, we...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935752/ https://www.ncbi.nlm.nih.gov/pubmed/29728574 http://dx.doi.org/10.1038/s41598-018-25384-x |