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A two-stage design with two co-primary endpoints
Two-stage designs are commonly used in phase II oncology trial to mitigate the risk of exposing patients to an inefficacious drug. Typically, the decision of moving into stage 2 enrollment is made based on response rate in stage 1 patients; and trials are designed in the hypothesis testing framework...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935830/ https://www.ncbi.nlm.nih.gov/pubmed/29736433 http://dx.doi.org/10.1016/j.conctc.2015.08.002 |